期刊
CANCER LETTERS
卷 250, 期 1, 页码 36-46出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2006.09.013
关键词
apoptosis; aquaporin; hepatocellular carcinoma; apoptotic volume decrease
类别
资金
- NCI NIH HHS [R01 CA090895, R01 CA090895-04, CA90895] Funding Source: Medline
Cells undergoing apoptosis are characterized by decreased cell size,due to changes in intracellular ion concentration and rapid, aquaporin (AQP)-dependent water movement out of the cell, events required for the activation of pro-apoptotic enzymes. The current study demonstrates AQP 8 and 9 expression is significantly decreased in hepatocellular carcinoma (HCC) versus normal liver. Isolation of hepatic tumor cells (H4IIE) and hepatocytes confirmed a lack of water movement across the H4IIE cell membrane via AQPs and identified an inherent resistance of H4IIE cells to apoptotic stimuli. In contrast, hepatocytes rapidly responded to osmotic challenge through AQP-dependent water movement and underwent cell death following apoptotic stimulation. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
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