期刊
JOURNAL OF COMPARATIVE NEUROLOGY
卷 502, 期 3, 页码 358-366出版社
WILEY
DOI: 10.1002/cne.21327
关键词
D-4 dopamine receptor; IL-opioid receptor; striatum; striosomes; receptor-receptor interaction; rat
The dopaminergic and opioid peptide systems interact in many nuclei of the brain. In the striatum, dopamine/opioid peptide interactions modulate locomotor and motivated behaviors as well as reward, motivational, and tolerance processes in opiate dependence. Dopamine D, receptors (D, R) and V-opioid receptors (MOR) are highly concentrated in the striosomes (islands) of the striatum, suggesting the existence of receptor-receptor interactions between them. In the present work we studied the role of D, R in modulating MOR expression in the islands by using immunohistochemistry and image analysis. The activation of D, R by the agonist PD168,077 (1 mg/kg) decreased MOR immunoreactivity (IR) in the striosomes 6 hours after drug treatment. MOR IR levels had recovered 12 hours later. Treatment with a D, R antagonist (L745,870, 1mg/kg) blocked downregulation of MOR IR, showing that the D-4 R agonist effects observed were specific. Furthermore, treatment with the D-2/D-3 receptor agonist quinpirol (1 mg/kg) and D,/D, receptor antagonist raclopride (1 mg/kg) had no effect in MOR IR, suggesting that D, R is the only D2-like receptor producing an MOR downregulation in the islands. The decreases of MOR IR in the striosomes suggest that D, R activation may reduce MOR signaling. Increasing evidence has demonstrated that the islands in the striatum play a critical role in habit acquisition during drug addiction. D-4 R/MOR interactions could be crucial in such processes.
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