期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 104, 期 21, 页码 8971-8976出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0609014104
关键词
CD4 T cells; coccoid form; dendritic cells; gastric epithelial cells; inflammation
Helicobacterpylori is a Gram-negative spiral bacterium that causes gastritis and peptic ulcer and has been implicated in the pathogenesis of gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma. Although Thl immunity is involved in gastritis and the accumulation of H. py/ori-specific CD4(+) T cells in theH.pylori-infected gastricmucosa in human patients, how T cells are primed with H. pylori antigens is unknown because no apparent lymphoid tissues are present in the stomach. We demonstrate here that Peyer's patches (PPs) in the small intestine play critical roles in H. pylori-induced gastritis; no gastritis is induced in H. py/ori-infected mice lacking PPs. Wealsoobserved thatthe coccoid form of H. pylori is phagocytosed by dendritic cells in PPs. We propose that H. pylori converts to the coccoid form intheanaerobIc small intestine and stimulates the host immune system through PPs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据