期刊
FEBS LETTERS
卷 581, 期 11, 页码 2125-2130出版社
WILEY
DOI: 10.1016/j.febslet.2007.01.090
关键词
Rab GTPases; tethering factor; rab effector; vesicular transport; endomembrane; Rab cascade
Rab GTPases are key proteins that determine organelle identity and operate at the center of fusion reactions. Like Ras, they act as switches that are connected to a diverse network of tethering factors, exchange factors and GTPase activating proteins. Recent studies suggest that Rabs are linked to each other via their effectors, thus coordinating protein transport in the endomembrane system. Within this review, we will focus on selected examples that highlight these issues. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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