期刊
FEBS LETTERS
卷 581, 期 11, 页码 2112-2118出版社
WILEY
DOI: 10.1016/j.febslet.2007.01.094
关键词
vesicular transport; actin; microtubules; dynein; kinesin; myosin
资金
- NIGMS NIH HHS [R01 GM068674, R01 GM068674-04] Funding Source: Medline
During vesicular transport, the assembly of the coat complexes and the selection of cargo proteins must be coordinated with the subsequent translocation of vesicles from the donor to an acceptor compartment. Here, we review recent progress toward uncovering the molecular mechanisms that connect transport vesicles to the protein machinery responsible for cytoskeleton-mediated motility. An emerging theme is that vesicle cargo proteins, either directly or through binding interactions with coat proteins, are able to influence cytoskeletal dynamics and motor protein function. Hence, a vesicle's cargo composition may help direct its intracellular motility and targeting. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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