期刊
NEUROSCIENCE LETTERS
卷 419, 期 1, 页码 1-4出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2007.03.044
关键词
TDP-43; frontotemporal lobar degeneration; FTLD; genetic association; PGRN
资金
- MRC [G0400356] Funding Source: UKRI
- Medical Research Council [G0400356] Funding Source: researchfish
- Medical Research Council [G0400356] Funding Source: Medline
It has recently been established that the ubiquitinated neuronal inclusions and neurites observed in frontotemporal lobar degeneration(FTLD) contain the TAR DNA-binding protein, TDP-43. It is not uncommon for genetic variation of genes that encode proteins that accumulate in neurodegenerative conditions to increase risk for disease. We therefore examined whether variation of the TDP-43 locus was associated with an increased risk of disease in the Manchester FTLD cohort. We found no evidence of TDP-43 variation increasing risk for FTLD in this cohort. These data suggest that TDP-43 accumulation is a consequence of the disease process underlying FTLD. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
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