期刊
NEURON
卷 54, 期 4, 页码 511-533出版社
CELL PRESS
DOI: 10.1016/j.neuron.2007.04.026
关键词
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资金
- NHLBI NIH HHS [R01 HL080050-03, R01 HL080050] Funding Source: Medline
- NIDCD NIH HHS [R01 DC007664-03S1, R01 DC007664] Funding Source: Medline
- NINDS NIH HHS [R01 NS049272-02, R01 NS049272] Funding Source: Medline
Structural biology now plays a prominent role in addressing questions central to understanding how excitable cells function. Although interest in the insights gained from the definition and dissection of macromolecular anatomy is high, many neurobiologists remain unfamiliar with the methods employed. This primer aims to help neurobiologists understand approaches for probing macromolecular structure and where the limits and challenges remain. Using examples of macromolecules with neurobiological importance, the review covers X-ray crystallography, electron microscopy (EM), small-angle X-ray scattering (SAXS), and nuclear magnetic resonance (NMR) and biophysical methods with which these approaches are often paired: isothermal titration calorimetry (ITC), equilibrium analytical ultracentifugation, and molecular dynamics (MD).
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