期刊
PHYSICAL REVIEW LETTERS
卷 98, 期 21, 页码 -出版社
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevLett.98.218101
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Fusion of bilayer membranes is studied via dissipative particle dynamics (DPD) simulations. A new set of DPD parameters is introduced which leads to an energy barrier for flips of lipid molecules between adhering membranes. A large number of fusion events is monitored for a vesicle in contact with a planar membrane. Several time scales of the fusion process are found to depend exponentially on the membrane tension. This implies an energy barrier of about 10k(B)T for intermembrane flips and a second size-dependent barrier for the nucleation of a small hemifused membrane patch.
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