期刊
NEUROSCIENCE LETTERS
卷 419, 期 2, 页码 153-157出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2007.04.040
关键词
phosphorylation; MAP kinase; potassium conductance; neuropathic pain; nerve injury
We examined the roles of phosphorylation of extracellular signal-regulated protein kinases (pERK) in regulating the excitability of neurons in the dorsal root ganglion (DRG) after chronic compression. A chronic compression of DRG (CCD) induced a significant increase in pERK in intact L4/L5 DRGs of rats as assessed by Western blot analysis. The treatment of U0126, the mitogen-activated protein kinase (MAPK) kinase 1/2 inhibitor, suppressed excitability in CCD-injured DRG neurons but not in naive DRG neurons. Furthermore, the inhibition of ERK signaling increased A-type fast inactivating potassium current. Taken together, the excitation of CCD neurons might be attributed to the CCD-induced activation of ERK, which suppressed the A-type fast inactivating potassium conductance in CCD neurons. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
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