期刊
FEBS LETTERS
卷 581, 期 13, 页码 2394-2400出版社
WILEY-BLACKWELL
DOI: 10.1016/j.febslet.2007.04.048
关键词
oxidative stress; 4-hydroxy-2-nonenal; cyclooxygenase; p38MAPK; adipocyte; 3T3-L1
Oxidative stress and low grade chronic inflammation are increased in accumulating fat. Our objective was to test whether 4-hydroxynonenal (4-HNE), an end-product of lipid peroxidation, affects cyclooxygenases in 3T3-L1 adipose cells. 4-HNE increased COX-2 mRNA and protein expression and p38MAP-kinase phosphorylation in a dose-dependent manner. Pretreatment of 3T3-L1 cells by a selective inhibitor of p38MAPK (PD 169316) abolished 4-HNE and glucose oxidase induced COX-2 expression. Our results show that oxidative stress induces COX-2 expression through the production of 4-HNE which activates p38MAP-Kinase, suggesting that 4-HNE links oxidative stress and chronic inflammation through the activation of cyclooxygenase. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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