期刊
FEBS LETTERS
卷 581, 期 13, 页码 2416-2422出版社
WILEY
DOI: 10.1016/j.febslet.2007.04.057
关键词
ADAM; adamalysin; reprolysin; MDC protein; metalloprotemase disintegrin; apoptotic toxin
Catrocollastatin/vascular apoptosis-inducing protein (VAP)2B is a metalloproteinase from Crotalus atrox venom, possessing metalloproteinase/disintegrin/cysteine-rich (MDC) domains that bear the typical domain architecture of a disintegrin and metalloproteinase (ADAM)/adamalysin/reprolysin family proteins. Here we describe crystal structures of catrocollastatin/VAP2B in three different crystal forms, representing the first reported crystal structures of a member of the monomeric class of this family of proteins. The overall structures show good agreement with both monomers of atypical homodimeric VAP1. Comparison of the six catrocollastatin/VAP2B monomer structures and the structures of VAP1 reveals a dynamic, modular architecture that may be important for the functions of ADAM/adamalysin/reprolysin family proteins. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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