期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 129, 期 21, 页码 6722-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja071990s
关键词
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资金
- NIGMS NIH HHS [T32 GM008496, R01 GM071779-01A1, R01 GM071779-02, GM08496, R01 GM071779, R01GM071779] Funding Source: Medline
Three-component coupling reactions between trialkylphosphines, methyl propiolates, and aldehydes produced 1:1:1 dipolar adducts in moderate to excellent yields. The product phosphonium enolate zwitterions were isolated as crystalline solids. X-ray crystallographic analyses of these single crystals established unequivocally the dipolar structures of these tetravalent phosphonium enolate zwitterions. Because phosphonium enolates are the first key intermediates in the nucleophilic phosphine-mediated catalysis of alpha,beta-unsaturated carbonyl compounds, this study provides crucial insight into the mechanisms of Morita-Baylis-Hillman-type reactions.
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