期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 129, 期 21, 页码 6807-6811出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja0692480
关键词
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资金
- NIGMS NIH HHS [R01 GM074070-03, R01 GM074070, GM074070] Funding Source: Medline
Chemotactic bacteria navigate their chemical environment by coupling sophisticated information processing capabilities to molecular motors that propel the cells forward. The ability to reprogram bacteria to follow entirely new chemical signals would create powerful new opportunities in bioremediation, bionanotechnology, and synthetic biology. However, the complexities of bacterial signaling and limitations of current protein engineering methods combine to make reprogramming bacteria to follow novel molecules a difficult task. Here we show that by using a synthetic riboswitch rather than an engineered protein to recognize a ligand, E. coli can be guided toward and precisely localized to a completely new chemical signal.
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