期刊
CELL CYCLE
卷 6, 期 11, 页码 1288-1292出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.6.11.4299
关键词
mRNA-binding protein; mRNA turnover; translational control; ELAV; SIRT1; ProT alpha; Bcl-2; Mcl-1
类别
资金
- Intramural NIH HHS Funding Source: Medline
The RNA-binding protein HuR can stabilize and/ or regulate the translation of target mRNAs, thereby affecting the cellular responses to immune, proliferative, and damaging agents. Here, we discuss emerging evidence that HuR elicits a broad anti-apoptotic function through its influence on the expression of multiple target mRNAs. HuR was previously shown to bind to the mRNA encoding the apoptosome inhibitor prothymosin a (ProT alpha) and enhanced its translation and cytoplasmic abundance. More recently, HuR was shown to increase the stability of a target mRNA encoding the pro-survival deacety lase SIRT1. The discovery that HuR likewise binds to and promotes the expression of mRNAs encoding Bcl-2 and Mcl-1, two major anti-apoptotic effectors, strongly supports HuR's role as a key upstream coordinator of a constitutive pro-survival program.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据