期刊
ARCHIVES OF TOXICOLOGY
卷 81, 期 6, 页码 441-446出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00204-006-0164-3
关键词
carbon black (CB) particles; reactive oxygen species (ROS); alveolar macrophages (AM); intracellular signalling pathways
类别
Alveolar macrophages (AM) have an important role in clearing particles from the lungs. In response to different stimuli they can release reactive oxygen species (ROS) and inflammatory mediators and promote pulmonary inflammation. We exposed rat AM to carbon black (CB) particles (0.63-20 mu g/ml) and measured the generation of ROS by using the fluorescent probe 2 ',7 '-dichlorofluorescein diacetate. Fluorescence was elevated in a concentration dependent manner in the AM exposed to CB. Follow-up experiments using a series of enzyme inhibitors indicate that the ERK MAP kinase pathway and the p38 MAP kinase pathway may be involved in the formation of ROS.
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