期刊
FUNDAMENTAL & CLINICAL PHARMACOLOGY
卷 21, 期 3, 页码 281-289出版社
WILEY
DOI: 10.1111/j.1472-8206.2007.00470.x
关键词
cytomegalovirus; p53-family gene; tumour; Z-ajoene
Z-ajoene is a garlic-derived compound with known anti-tumour properties. This report argues in favour of pro-apoptotic and cell cycle blockage activities of Z-ajoene on various cell lines involving activation of the p53-family gene products, p53, p63 and p73, at indicated doses. According to its known anti-proteasome activity, Z-ajoene induced a downregulation of MHC-class I expression at the surface of treated cells but did not impair their recognition by CD8(+) T cells. We further demonstrated a new activity of Z-ajoene against human cytomegalovirus spreading in vitro that was mediated by an increased number of apoptotic cells after infection. Altogether our data point at the ubiquitous efficiency of Z-ajoene as a new compound to fight against cancers of various origins including those that put up viruses.
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