期刊
NATURE REVIEWS MICROBIOLOGY
卷 5, 期 6, 页码 431-440出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro1659
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- MRC [G0400277] Funding Source: UKRI
- Medical Research Council [G0400277] Funding Source: researchfish
- Medical Research Council [G0400277(70731), G0400277] Funding Source: Medline
- Wellcome Trust [GR077564MA, 077564] Funding Source: Medline
Bacterial mechanosensitive channels are activated by increases in tension in the lipid bilayer of the cytoplasmic membrane, where they transiently create large pores in a controlled manner. Mechanosensitive channel research has benefited from advances in electrophysiology, genomics and molecular genetics as well as from the application of biophysical techniques. Most recently, new analytical methods have been used to complement existing knowledge and generate insights into the molecular interactions that take place between mechanosensitive channel proteins and the surrounding membrane lipids. This article reviews the latest developments.
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