期刊
MOLECULAR BIOLOGY AND EVOLUTION
卷 24, 期 6, 页码 1397-1406出版社
OXFORD UNIV PRESS
DOI: 10.1093/molbev/msm056
关键词
adaptation; experimental evolution; clonal interference; mutation
资金
- NIGMS NIH HHS [R01 GM069801] Funding Source: Medline
When a beneficial mutation is fixed in a population that lacks recombination, the genetic background linked to that mutation is fixed. As a result, beneficial mutations on different backgrounds experience competition, or clonal interference, that can cause asexual populations to evolve more slowly than their sexual counterparts. Factors such as a large population size (N) and high mutation rates (p) increase the number of competing beneficial mutations, and hence are expected to increase the intensity of clonal interference. However, recent theory suggests that, with very large values of N mu, the severity of clonal interference may instead decline. The reason is that, with large N mu, genomes including both beneficial mutations are rapidly created by recurrent mutation, obviating the need for recombination. Here, we analyze data from experimentally evolved asexual populations of a bacteriophage and find that, in these nonrecombining populations with very large Np, recurrent mutation does appear to ameliorate this cost of asexuality.
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