期刊
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
卷 295, 期 9, 页码 1473-1481出版社
WILEY-BLACKWELL
DOI: 10.1002/ar.22530
关键词
islet; vasculature; pancreas
The pancreatic islets of Langerhans are highly vascularized structures scattered throughout the pancreas that contain a capillary network 510 times denser than that of the exocrine pancreas. A simple method for three-dimensional (3D) analysis of this intricate intraislet vasculature has been difficult because of the intrinsic opacity of the pancreas. We developed a whole-mount imaging technique that allows relatively easy visualization of the islet vasculature. In combination with confocal microscopy and the use of 3D imaging software, we were able to readily reconstruct the 3D architecture of an islet, allowing delineation of the islet volume, length of the intraislet vessels, and the number of vessel branch-points. This technique allows for straightforward 3D image analysis that may help toward understanding islet function. Anat Rec, 2012. (C) 2012 Wiley Periodicals, Inc.
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