期刊
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
卷 295, 期 9, 页码 1455-1461出版社
WILEY-BLACKWELL
DOI: 10.1002/ar.22523
关键词
mitochondrial division; mitochondrial pinching; cardiac; heart
资金
- National Institute on Aging [P01 AG015885]
In cardiomyocytes of rats, two distinct mitochondrial division processes are in operation. The predominant process involves extension of a single crista until it spans the full width of a mitochondrion. Ingrowth of the outer membrane ultimately results in scission. The second division process involves pinching, in which narrowing of the organelle at specific surface locations leads to its attenuation. When limiting membranes from opposite sides meet, mitochondrial fission ensues. When pinching is the operative mode, elements of sarcoplasmic reticulum always are associated with the membrane constrictions. The nuclear control mechanisms that determine which modality of mitochondrial division will prevail are unknown. Anat Rec, 2012. (C) 2012 Wiley Periodicals, Inc.
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