期刊
MOLECULAR NEUROBIOLOGY
卷 35, 期 3, 页码 298-307出版社
SPRINGER
DOI: 10.1007/s12035-007-0022-1
关键词
neural development; plasticity; metabotropic glutamate receptors; mGluRs; fragile X syndrome; FRAX; epilepsy; malformation of cortical development
Group I metabotropic glutamate receptors ( mGlu1 and mGlu5) are coupled to polyphosphoinositide hydrolysis and are involved in activity-dependent forms of synaptic plasticity, both during development and in the adult life. Group I mGlu receptors can also regulate proliferation, differentiation, and survival of neural stem/progenitor cells, which further support their role in brain development. An exaggerated response to activation of mGlu5 receptors may underlie synaptic dysfunction in Fragile X syndrome, the most common inherited form of mental retardation. In addition, group I mGlu receptors are overexpressed in dysplastic neurons of focal cortical dysplasia and hemimegaloencephaly, which are disorders of cortical development associated with chronic epilepsy. Drugs that block the activity of group I mGlu receptors ( in particular, mGlu5 receptors) are potentially helpful for the treatment of Fragile X syndrome and perhaps other neurodevelopmental disorders.
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