期刊
EXPERIMENTAL GERONTOLOGY
卷 42, 期 6, 页码 463-471出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2007.03.003
关键词
C/EBP alpha; PPAR gamma; CUGBP; preadipocyte differentiation; dysdifferentiation
资金
- NIA NIH HHS [R01 AG023960, R37 AG013925, R01 AG023960-04S1, R01 AG013925, R01 AG013925-09, AG13925, AG23960] Funding Source: Medline
- NIDDK NIH HHS [R01 DK056891, R01 DK056891-05, DK56891] Funding Source: Medline
Fat mass and tissue distribution change dramatically throughout life. Fat depot sizes reach a peak by middle or early old age, followed by a substantial decline, together with fat tissue dysfunction and redistribution in advanced old age. These changes ate associated with health complications, including type 2 diabetes, atherosclerosis, dyslipidemia, thermal dysregulation, and skin ulcers, particularly in advanced old age. Fat tissue growth occurs through increases in size and number of fat cells. Fat cells turn over throughout the lifespan, with new fat cells developing from preadipocytes, which are of mesenchymal origin. The pool of preadipocytes comprises 15-50% of the cells in fat tissue. Since fat tissue turns over throughout life, characteristics of these cells very likely have a significant impact on fat tissue growth, plasticity, function, and distribution. The aims of this review are to highlight recent findings regarding changes in preadipocyte cell dynamics and function with aging, and to consider how inherent characteristics of these cells potentially contribute to age- and depot-dependent changes in fat tissue development and function. (c) 2007 Elsevier Inc. All rights reserved.
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