期刊
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
卷 293, 期 6, 页码 955-967出版社
WILEY
DOI: 10.1002/ar.20895
关键词
extracellular matrix; heparan sulfates; lung; emphysema; patho(physiology)
资金
- NIA NIH HHS [R01 AG023590] Funding Source: Medline
- NATIONAL INSTITUTE ON AGING [R01AG023590] Funding Source: NIH RePORTER
There is an emerging interest in the extracellular matrix (ECM) of the lung, especially in the role it plays in development and disease There is a rapid change from the classical view of the ECM as a supporting structure towards a view of the ECM as a regulatory entity with profound effects on proliferation, migration, and differentiation of pulmonary cells. In the ECM, a variety of molecules is present in a highly organized pattern Next to the abundant fiber-forming molecules such as collagens and elastin, a large number of less abundant molecules are part of the ECM, including proteoglycans In this review, we will focus on one class of proteoglycans, the heparan sulfate proteoglycans We will particularly address the structure, biosynthesis, and function of their saccharide moiety, the heparan sulfates, including their role in development and (patho)physiology. Anat Rec, 293 955-967, 2010 (C) 2010 Wiley-Liss, Inc.
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