期刊
DRUG DISCOVERY TODAY
卷 12, 期 11-12, 页码 459-464出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2007.04.004
关键词
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Here, we detail the major developments in methods and techniques that are applicable to high-throughput synthesis that have evolved over the past five years, with an emphasis on the combination of microwave-based synthesis with techniques such as polymer-assisted purification and immobilized reagents and catalysts. Other aspects, such as automation, miniaturization and flow-based synthesis, are also presented as approaches that can be used for the rapid discovery and optimization of small organic molecules.
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