期刊
MITOCHONDRION
卷 7, 期 -, 页码 S94-S102出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2007.02.007
关键词
mitochondria; antioxidants; MitoQ
资金
- Medical Research Council [MC_U105663142] Funding Source: researchfish
- MRC [MC_U105663142] Funding Source: UKRI
- Medical Research Council [MC_U105663142] Funding Source: Medline
Mitochondrial oxidative damage contributes to a range of degenerative diseases. Ubiquinones have been shown to protect mitochondria from oxidative damage, but only a small proportion of externally administered ubiquinone is taken up by mitochondria. Conjugation of the lipophilic triphenylphosphonium cation to a ubiquinone moiety has produced a compound, MitoQ, which accumulates selectively into mitochondria. MitoQ passes easily through all biological membranes and, because of its positive charge, is accumulated several hundred-fold within mitochondria driven by the mitochondrial membrane potential. MitoQ protects mitochondria against oxidative damage in vitro and following oral delivery, and may therefore form the basis for mitochondria-protective therapies. (c) 2007 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
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