期刊
NATURE BIOTECHNOLOGY
卷 25, 期 6, 页码 660-662出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nbt1308
关键词
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Many signaling proteins are built from simple, modular components, yet display highly complex signal-processing behavior. Here we explore how modular domains can be used to build an ultrasensitive switch-a nonlinear input/output function that is central to many complex biological behaviors. By systematically altering the number and affinity of modular autoinhibitory interactions, we show that we can predictably convert a simple linear signaling protein into an ultrasensitive switch.
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