期刊
HAEMATOLOGICA
卷 92, 期 6, 页码 834-837出版社
FERRATA STORTI FOUNDATION
DOI: 10.3324/haematol.11064
关键词
chronic myeloid leukemia; cytogenetics; clonal evolution; tyrosine kinase inhibitors; dasatinib
类别
资金
- competence network 'Acute and chronic leukemias' - German Bundesministerium fur Bildung und Forschung (Projekttrager Gesundheitsforschung
- DLR e.V.)
- Bristol-Myers Squibb, New York, NY
Clonal cytogenetic aberrations of the Philadelphia chromosome (Ph) positive hematopoiesis have been associated with the natural evolution of chronic myeloid leukemia (CML) to advanced disease. Clonal aberrations of Ph negative metaphases have been described after treatment with interferon or imatinib. This study evaluates the effect of dasatinib on Ph positive clones with additional cytogenetic aberrations and the frequency of novel aberrations in Ph positive and negative metaphases. Seventy-one patients treated with dasatinib after imatinib failure for a median of nine months were evaluated. Novel aberrations within Ph positive and negative clones appeared in six and three patients, respectively.
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