期刊
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
卷 13, 期 1-2, 页码 53-68出版社
SPRINGER
DOI: 10.1007/s10989-006-9053-0
关键词
oligonucleotide; non-natural bases; oligonucleotide-peptide conjugates; nanomaterials; self-assembly; solid phase synthesis
Synthetic oligonucleotides are ubiquitously found in most laboratories since solid-phase synthesis protocols have become highly optimized. These protocols make it possible to synthesize a large variety of modified oligonucleotides. As one example, we will review some of the developments regarding oligonucleotide synthesis from our own group. In particular, we will describe the synthesis of oligonucleotides carrying non-natural bases, of oligonucleotide-peptide conjugates, and of modified oligonucleotides used in the assembly of nanomaterials.
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