期刊
JOURNAL OF PSYCHOPHARMACOLOGY
卷 21, 期 4, 页码 435-439出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0269881106067787
关键词
bipolar disorder; omega-3 fatty acid; eicosapentanoic acid; magnetic resonance spectroscopy
Ethyl-eicosapentanoic acid (ethyl-EPA) may be beneficial in the treatment of bipolar disorder (BD) and may have a neurotrophic/neuroprotective rote in patients with neuropsychiatric disorders. To investigate this we examined whether ethyl-EPA treatment of BD patients is associated with increased brain levels of N-acetyl-aspartate (NAA), a putative marker of neuronal integrity. Fourteen female ED outpatients with moderate depressive symptoms were administered 2 g of ethyl-EPA per day or placebo for 12 weeks in a randomized, double-blind fashion. Quantitative, proton magnetic resonance spectroscopy imaging data were obtained prior to randomization and after 12 weeks of treatment from a single 12 ml volume of interest centred above the body of the corpus callosum. A significant rise in NAA levels was observed in the ethyl-EPA treatment group compared with the placebo group (p=0.027). These results provide the first evidence for a probable neurotrophic role of ethyl-EPA treatment in ED underlining the need for more detailed investigation of its mechanism of action and therapeutic potential.
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