期刊
BIOCHIMIE
卷 89, 期 6-7, 页码 754-760出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biochi.2007.01.013
关键词
interferon; RNA helicase; innate immunity; TLR; double-stranded RNA
TLRs detect several classes of virus-associated molecules, such as ssRNA, CpG-DNA and dsRNA, and transduce signals leading to the production of IFN. Recently discovered cytoplasmic RNA helicases, RIG-I and MDA5, selectively sense viral RNA species. Gene disruption studies revealed the critical but non-redundant function of RIG-I and MDA5 in host antiviral responses. (C) 2007 Elsevier Masson SAS. All rights reserved.
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