期刊
JOURNAL OF NEUROPHYSIOLOGY
卷 97, 期 6, 页码 3986-3996出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/jn.00141.2007
关键词
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资金
- NEI NIH HHS [EY-11027] Funding Source: Medline
Neural circuits are composed of diverse cell types, the firing properties of which reflect their intrinsic ionic currents. GABAergic and non-GABAergic neurons in the medial vestibular nuclei, identified in GIN and YFP-16 lines of transgenic mice, respectively, exhibit different firing properties in brain slices. The intrinsic ionic currents of these cell types were investigated in acutely dissociated neurons from 3- to 4-wk-old mice, where differences in spontaneous firing and action potential parameters observed in slice preparations are preserved. Both GIN and YFP-16 neurons express a combination of four major outward currents: Ca2+ -dependent K+ currents ( IKCa), 1 mM TEA-sensitive delayed rectifier K+ currents (I-1TEA), 10 mM TEA-sensitive delayed rectifier K+ currents (I-10TEA), and A-type K+ currents ( I A). The balance of these currents varied across cells, with GIN neurons tending to express proportionately more I-KCa and I-A, and YFP- 16 neurons tending to express proportionately more I-1TEA and I-10TEA. Correlations in charge densities suggested that several currents were coregulated. Variations in the kinetics and density of I-1TEA could account for differences in repolarization rates observed both within and between cell types. These data indicate that diversity in the firing properties of GABAergic and non-GABAergic vestibular nucleus neurons arises from graded differences in the balance and kinetics of ionic currents.
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