期刊
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
卷 21, 期 2, 页码 209-221出版社
BAILLIERE TINDALL
DOI: 10.1016/j.beem.2007.03.004
关键词
organic anion transporting polypeptides; T-3; T-4; thyroid hormone; transport
资金
- NCRR NIH HHS [P20 RR021940] Funding Source: Medline
Several transporter families that can transport thyroid hormones have been identified. One of these is represented by the organic anion transporting polypeptide (OATP) gene superfamily, classified within the solute carrier family SLCO. In humans, eleven different OATPs are expressed in various tissues, including the liver, kidney, brain, lung, intestine and placenta. They mediate sodium-independent transport of a variety of amphipathic organic compounds, including thyroid hormones, bile acids, steroid hormones and their conjugates, linear and cyclic pepticles, prostaglandins, numerous drugs and other xenobiotics. OATP1OC1, which is expressed in the blood-brain barrier and testes, is the thyroid hormone transporter with the highest apparent affinity, with K-m values of 90.4 nM for thyroxine (T-4) and 127.7 nM for reverse T-3 (rT(3)) transport, and could be essential for thyroid hormone delivery to the developing brain. OATP4A1 is expressed in the placenta and could be important for maternal thyroid hormone transport to the developing fetus.
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