期刊
CURRENT OPINION IN NEUROBIOLOGY
卷 17, 期 3, 页码 360-365出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2007.03.012
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Endogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. They are released from postsynaptic neurons and cause transient and long-lasting reduction of neurotransmitter release through activation of presynaptic cannabinoid receptors. Endocannabinoid release is induced either by increased postsynaptic Ca2+ levels or by activation of G(q/11)-coupled receptors. When these two stimuli coincide, endocannabinoid release is markedly enhanced, which is attributed to the Ca2+ dependency of phospholipase C beta (PLC beta). This Ca2+-assisted receptor-driven endocannabinoid release is suggested to participate in various forms of synaptic plasticity, including short-term associative plasticity in the cerebellum and spike-timing-dependent long-term depression in the somatosensory cortex. In these forms of plasticity, PLC beta seems to function as a coincident detector of presynaptic and postsynaptic activities.
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