期刊
ANALYTICAL SCIENCES
卷 26, 期 6, 页码 715-718出版社
JAPAN SOC ANALYTICAL CHEMISTRY
DOI: 10.2116/analsci.26.715
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资金
- MEXT
- Tosoh Corp.
The effects of an on-line ion suppressor device on alkali metal ion adduct formations of the model compound tacrolimus were investigated. The base peak ion in the positive ion ESI-MS spectrum of tacrolimus was a sodium ion adduct, [M+Na](+). On the other hand, an ammonium ion adduct, [M+NH4](+), was the base peak ion in the full-scan mass spectrum of tacrolimus with a cation-exchange suppressor resin, and both [M+Na](+) and [M+K](+) were eliminated. These results indicate that the combination of an on-line ion suppressor with ESI-MS is a simple and effective technique that eliminates undesirable alkali metal ion adduct formations in the positive-ion mode.
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