期刊
VIRUS RESEARCH
卷 126, 期 1-2, 页码 245-249出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.virusres.2007.03.006
关键词
hepatitis B virus; interleukin 29 proteins; virus replication; receptors; interferon
类别
资金
- National Research Foundation of Korea [과C6A2602] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The antiviral activity of interferon-lambda (IFN-lambda) against several viruses has been reported, but it has not been investigated whether human IFN-lambda can affect replication of the hepatitis B virus (HBV) in human hepatocyte-derived cells. We found that replication of HBV in a human hepatoma cell line was reduced by approximately 30% following treatment with a high concentration of IFN-lambda. Furthermore, we showed that replication of HBV in another human hepatoma cell line was not suppressed by IFN-lambda. However, these cell lines showed a similar level of transcription for the heterodimeric IFN-lambda receptor and the IFN-lambda-induced antiviral proteins. Our results suggest that the antiviral activity of IFN-lambda against HBV may be limited in human cells. (C) 2007 Elsevier B.V. All rights reserved.
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