期刊
CELL CYCLE
卷 6, 期 11, 页码 1336-1341出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.6.11.4359
关键词
combination therapy; synergy; pharmacogenetic synergy; pharmacogenetic window; targeted therapy
类别
资金
- NCI NIH HHS [CA62924] Funding Source: Medline
Single therapeutic agents very often fail in unselected patients. It is therefore common place to combine an agent specifically with a selected patient subgroup or with another agent. To support such efforts, it is useful to clarify the distinctions between the terms and the mathematical models used in analyzing combinations. To incorporate molecular disease classifications, the familiar concept of the therapeutic window is modified to define a pharmacogenetic window, which is an unambiguous numerical measure of the magnitude of interaction produced by a combination, and to define a test of pharma cogenetic synergy. In contrast, certain common comparative methods, such as vertical windows (comparing effects at a given dose) and animal models of mutational targets may be dominated by undesirable features. Although this discussion is oriented towards cancer therapy, an extension of these concepts to other comparative biologic assays is feasible and advisable.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据