期刊
JOURNAL OF BIOLOGICAL RHYTHMS
卷 22, 期 3, 页码 211-219出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0748730407301238
关键词
suprachiasmatic nucleus; coupled oscillators; Kuramoto model
资金
- NIMH NIH HHS [R01 MH06310405] Funding Source: Medline
- NINDS NIH HHS [R01 NS6605] Funding Source: Medline
The suprachiasmatic nucleus (SCN) in the hypothalamus is the site of the master circadian clock in mammals, a complex tissue composed of multiple, coupled, single-cell circadian oscillators. Mathematical modeling is now providing insights on how individual SCN cells might interact and assemble to create an integrated pacemaker that governs the circadian behavior of whole animals. In this article, we will discuss the neurobiological constraints for modeling SCN behavior, system precision, implications of cellular heterogeneity, and analysis of heterogeneously coupled oscillator networks. Mathematical approaches will be critical for better understanding intercellular interactions within the SCN.
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