期刊
SYNLETT
卷 -, 期 9, 页码 1431-1435出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2007-980368
关键词
combinatorial chemistry; solid-phase synthesis; quinolinone; Dieckmann condensation; cyclative cleavage
Utilizing polymer-bound anthranilic acid derivatives, we were able to obtain 4-hydroxyquinolin-2(1H)-ones in 50-99% five- or six-step overall yields and 65-95% purities through the adaptation of a Dieckmann-type condensation reaction to a C-C bond-forming cyclative cleavage step. The reactions on solid phase were monitored by on-bead ATR-FTIR spectroscopic methods, colorimetric tests, and/or cleavage experiments.
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