期刊
CLINICAL NEUROPHYSIOLOGY
卷 118, 期 6, 页码 1369-1376出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.clinph.2007.02.027
关键词
electroencephalography; databases; alpha rhythm; background activity; asymmetry; topography
Objective: To study the age-related topographical tendency of expressing epileptiform activity, and the effect of focal epileptiform activity (FEA) on the general cortical brain activity. Methods: 1647 consecutive routine EEGs containing FEA were visually assessed for FEA location and asymmetry. Background activity was compared with that in normal EEGs from 3268 drug-free outpatient controls. Results: FEA localisation was age-related (p < 0.0005) except for the temporal region (p = 0.22) where FEA was found equally often in the young and the old. The left hemisphere was more prone to FEA (p = 0.018). The left right asymmetry varied by age (p = 0.013). FEA asymmetry occurred most frequently in EEGs from patients older than 80 years, and least frequent in the age-group 20-39 years. FEA was associated with lower alpha rhythm (AR) frequencies (p = 0.0041) and higher AR amplitudes (p = 0.0023), as well as higher general background activity (GBA) amplitude (p < 0.0005), while GBA frequencies were the same (p = 0.96). Conclusions: Topographical localisation of FEA was age-dependent. There was an overall left dominance, but the side asymmetry was modest and varied by age. FEA was associated with changes in AR and GBA. Significance: The results demonstrate that FEA is associated with cerebral cortical dysfunction also distant from the epileptic focus. (C) 2007 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
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