期刊
IMMUNOLOGY AND CELL BIOLOGY
卷 85, 期 4, 页码 280-286出版社
WILEY
DOI: 10.1038/sj.icb.7100050
关键词
HTLV-1; HIV-1; mathematical model; kinetics; cytotoxic T lymphocytes
Despite significant advances in our understanding of the immune response to persistent viruses like human T-cell lymphotropic virus type I (HTLV-I), many important questions remain unanswered. Mathematical modelling enables us to interpret and synthesise diverse experimental data in new ways and thus can contribute to our understanding. Here, we review recent advances in mathematical modelling of HTLV-I infection and illustrate how mathematics has enabled us to identify factors that determine an individual's viral burden and risk of developing HTLV-I-associated diseases.
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