期刊
TOXICOLOGY AND APPLIED PHARMACOLOGY
卷 221, 期 2, 页码 131-147出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.taap.2007.03.001
关键词
manganese; Parkinson's disease; transport; neurotoxicity
资金
- NIEHS NIH HHS [R01 ES010563-07, R01 ES010563, ES10563, ES10975, ES008146, R01 ES008146, ES010975, R01 ES010563-06] Funding Source: Medline
The present review is based on presentations from the meeting of the Society of Toxicology in San Diego, CA (March 2006). It addresses recent developments in the understanding of the transport of manganese (Mn) into the central nervous system (CNS), as well as brain imaging and neurocognitive studies in non-human primates aimed at improving our understanding of the mechanisms of Mn neurotoxicity. Finally, we discuss potential therapeutic modalities for treating Mn intoxication in humans. (C) 2007 Elsevier Inc. All rights reserved.
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