期刊
JOURNAL OF BIOCHEMISTRY
卷 141, 期 6, 页码 775-781出版社
JAPANESE BIOCHEMICAL SOC
DOI: 10.1093/jb/mvm105
关键词
basic-leucine zipper structure; cell differentiation; oncogenic transformation; tissue-specific gene expression; transcriptional network
Maf family transcription factors are regulators of tissue-specific gene expression and cell-differentiation in a wide variety of tissues and are also involved in human diseases and oncogenic transformation. To establish tissue-specific expression, Maf binds to Maf-recognition elements (MAREs) in the regulatory regions of target genes, and functionally interacts with other transcription factors. For example, L-Maf and c-Maf, which are specifically expressed in developing lens cells, act synergistically with Sox proteins to induce lens-specific crystalline genes. MafA, a beta-cell-specific member of the Maf family, activates the insulin gene promoter synergistically with Pdx1 and Beta2 to establish beta-cell specific expression. Furthermore, in beta-cells, MafA activity is regulated at both the transcriptional and post-translational levels by glucose and oxidative stress. This review summarizes the functions and roles of Maf in various biological processes and recent progress in elucidating the mechanisms whereby Maf proteins regulate transcription.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据