期刊
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
卷 16, 期 6, 页码 1291-1293出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1055-9965.EPI-06-1089
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资金
- NCRR NIH HHS [M01-RR-00079, M01-RR-00083] Funding Source: Medline
- NHLBI NIH HHS [1R01HL083760-01] Funding Source: Medline
- NIAID NIH HHS [U01-AI-34993, U01-AI-34994, U01-AI-35004, U01-AI-42590, U01-AI-34989, U01-AI-31834, N01-AI-35161] Funding Source: Medline
- NICHD NIH HHS [U01-HD-32632] Funding Source: Medline
Objective: Novel biomarkers including proinflammatory cytokines and adipokines are being explored as potential mediators of cancer and other obesity-related conditions. Prospective studies linking biomarker levels with disease outcomes often measure biomarkers at a single time point and assume that the within-individual variation in levels is small compared with the interindividual variation. However, this assumption is seldom tested. Methods: This study examined the within-individual stability over time of plasma adiponectin, resistin, leptin, plasma activator inhibitor type 1, hepatocyte growth factor, tumor necrosis factor alpha, interleukin 6, and insulin among healthy young women. Results: The study included 17 women (9 Black non-Hispanic, 2 Black Hispanic, 2 White Hispanic, and 4 other index of 31.2 kg/m(2), and 76% prevalence of smoking. Analysis of intraclass correlation (ICC) suggested high to moderate correlation over repeated samples taken over 3 years in levels of resistin (ICC = 0.95), hepatocyte growth factor (0.91), plasma activator inhibitor type 1 (0.84), adiponectin (0.73), insulin (0.62), and leptin (0.58). ICCs were weaker for levels of proinflammatory cytokines, tumor necrosis factor alpha (0.39), and interleukin 6 (0.47). Conclusion: In this population of minority young females with a high prevalence of overweight and smoking, several obesity-related endocrine markers were stable over a period of 3 years. This supports the feasibility of longitudinal studies relating these biomarkers to the future occurrence of cancer and other health consequences of obesity.
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