期刊
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
卷 3, 期 2, 页码 132-137出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.nano.2007.03.001
关键词
hyaluronic acid; iron oxide particles; hybrid nanoparticles; drug targeting systems and cell targeting
资金
- NHLBI NIH HHS [5R01HL71101-01A2] Funding Source: Medline
Novel hybrid nanoparticles comprised of hyaluronic acid (HA) and iron oxide were synthesized and characterized for the first time with the average diameter of less than 160 nm. The iron oxide (Fe2O3) particles are hybridized between HA layers by electrostatic interactions between the positive surface charge of the Fe2O3 nanoparticles and the negative charge of the carboxylate groups of HA, forming a corral-like structure. The particles were also characterized by FTIR and NMR to verify the hybridization. The particles were tested for their ability to deliver peptides to the cells using HEK293 and A549 cells. Results show that these particles delivered peptides at about 100% level. These HA-iron oxide nanoparticles are expected to be useful in developing effective tissue and cell targeting systems. (c) 2007 Elsevier Inc. All rights reserved.
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