期刊
ANALYTICAL METHODS
卷 6, 期 21, 页码 8476-8481出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ay01881h
关键词
-
资金
- 973 Program [2012CB720600, 2012CB720601]
- National Natural Science Foundation of China [21372021]
A natural flexible cyclic molecule, fangchinoline (FAN) from traditional Chinese medicine, was found with a good binding affinity and thermodynamic stabilization effect on a bcl2 G-quadruplex. Further studies showed that fangchinoline could induce the formation and the conformational conversion of G-quadruplexes from a mixed parallel/anti-parallel to a parallel stranded structure. Our study provided a novel G-quadruplex ligand facilitating the structural conversion of the G-quadruplex, which implied that this fangchinoline could be used to regulate biological activities of the G-quadruplex DNA.
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