期刊
PSYCHOSOMATICS
卷 48, 期 3, 页码 205-210出版社
AMER PSYCHIATRIC PUBLISHING, INC
DOI: 10.1176/appi.psy.48.3.205
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The authors conducted a retrospective cohort study of female patients diagnosed with breast cancer (BRCA), evaluating the risk of new-onset depression associated with tamoxifen treatment among those with estrogen receptor-positive (ER +) tumors, versus estrogen receptor-negative (ER-) tumors, who were not receiving tamoxifen. A total cohort of 2,943 patients was identified. The hazard-ratio for new-onset depression in the tamoxifen group was nonsignificant. A post-hoc analysis revealed that chemotherapy and ER + status were significantly and independently associated with an increased risk for developing depression.
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