期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 16, 期 7, 页码 15442-15455出版社
MDPI
DOI: 10.3390/ijms160715442
关键词
inflammation; leukocyte; evolution; chemoattractant
资金
- NIAID Division of Intramural Research [AI000941, AI000942, AI000943]
The eosinophil-derived neurotoxin (EDN/RNase2) and its divergent orthologs, the mouse eosinophil-associated RNases (mEars), are prominent secretory proteins of eosinophilic leukocytes and are all members of the larger family of RNase A-type ribonucleases. While EDN has broad antiviral activity, targeting RNA viruses via mechanisms that may require enzymatic activity, more recent studies have elucidated how these RNases may generate host defense via roles in promoting leukocyte activation, maturation, and chemotaxis. This review provides an update on recent discoveries, and highlights the versatility of this family in promoting innate immunity.
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