期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 17, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/ijms17010048
关键词
pancreatic progenitor; Notch signaling; differentiation; maintenance
资金
- National Natural Science Foundation of China [31472159, J1210053]
The Notch signaling pathway plays a significant role in embryonic cell fate determination and adult tissue homeostasis. Various studies have demonstrated the deep involvement of Notch signaling in the development of the pancreas and the lateral inhibition of Notch signaling in pancreatic progenitor differentiation and maintenance. The targeted inactivation of the Notch pathway components promotes premature differentiation of the endocrine pancreas. However, there is still the contrary opinion that Notch signaling specifies the endocrine lineage. Here, we review the current knowledge of the Notch signaling pathway in pancreatic development and its crosstalk with the Wingless and INT-1 (Wnt) and fibroblast growth factor (FGF) pathways.
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