期刊
JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS
卷 55, 期 6, 页码 1166-1181出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmps.2006.12.001
关键词
adhesion; surface diffusion; membrane; vesicle; finite elements
A continuum model was introduced for the adhesion of vesicles to substrate surfaces. In the model, the vesicle membrane was assumed to be a closed shell with hyperelasticity. The vesicle cavity is filled with a liquid of fixed volume. The receptors on the membrane are mobile and initially uniformly distributed while the ligands on the substrate surface are fixed and also uniformly distributed. The formation of localized regions of tight binding between receptors and ligands, results in vesicle adhesion to the substrate surface. An adhesive model was introduced to describe the adhesive interaction between the receptors and the ligands. The growth of the adhesion area occurs via recruiting receptors from the non-adhered region through diffusion. Finite-element methods were used to solve the governing equations for the deformation of the vesicle and the receptor diffusion on the membrane surface. Effects of the membrane stiffness, the cohesive parameters and the receptor density on the adhesion kinetics of the vesicle were studied. In addition, the instability of the advancing front of the adhesion was also analyzed. (c) 2007 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据