期刊
TRENDS IN IMMUNOLOGY
卷 28, 期 6, 页码 267-273出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2007.04.008
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资金
- Biotechnology and Biological Sciences Research Council [JF19128] Funding Source: Medline
- Biotechnology and Biological Sciences Research Council [JF19128] Funding Source: researchfish
T-cell-receptor triggering and the delivery of co-stimulation are essential events leading to T cell expansion, differentiation and effector function. The influence that such signals exert on T cell migration during and following priming has been highlighted by recent reports. Moreover, induction of peripheral tolerance might act in part by affecting T cell migration. Here, we propose that the integration of co-stimulatory signals, which regulate the ability of primed T cells to access nonlymphoid tissue, and cognate recognition of the endothelium, which determines the selective recruitment of specific T cells, contribute to the anatomy of T cell-mediated immunity and tolerance. The implications for therapeutic strategies manipulating these signals are discussed.
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